Persantine (Dipyridamole)

What is Persantine?

Persantine (dipyridamole) is an oral platelet inhibitor which prevents formation of blood clots.

What is Persantine used for?

Persantine is used, with blood thinners, to prevent formation of blood clots (serious complications that can result in heart attacks, strokes, or pulmonary embolisms). It is usually used after a heart valve replacement surgery. It is often prescribed in combination with anti-coagulants.

How does Persantine work?

Though the way Persantine works is yet to be fully understood it is presumed that it increases the levels of adenosine (a body chemical) which in turn widens blood vessels and reduces platelet activity. It stops platelets from clumping together and keeps heart blood vessels open.

How to use Persantine

Persantine should be used in the manner prescribed by a doctor. Taking the drug in larger amounts or for longer periods of time than prescribed can prove to be harmful.

The dosage of Persantine depends on your medical condition and response to treatment.

Persantine is usually taken orally on an empty stomach (at least one hour before or 2 hours after eating). If you experience upset stomach you can take the medicine with food.

Do not increase the dose or stop taking the medicine unless directed by your doctor.

Persantine warnings and precautions

Persantine is not administered to patients who are allergic to any ingredient in it.

Prior to taking the medication inform your doctor if you are allergic to any other drug or have any of the following conditions: chest pain, any heart disease (especially if you had a recent heart attack), or any liver problem.

Persantine should not be given to children younger than 12 years old. It should be used with caution when given to the elderly.

Effects of Persantine on fetus are not known for certain, however, it is believed to pass through breast milk. Therefore, pregnant and lactating women are advised to discuss the possible risks and benefits of Persantine with their respective doctors. Also inform your doctor if you plan to become pregnant during treatment.

What do I do if I have missed a Persantine dose?

If you have missed a Persantine dose, take it as soon as you remember. If, however, it is almost time for the next dose, the missed dose can be skipped. No matter what, a double dose should never be taken.

What do I do if I have taken a Persantine overdose?

If you have taken an overdose of Persantine, consult your doctor immediately.

Persantine interactions

Persantine may interact with adenosine and can cause side-effects such as low blood pressure and irregular heartbeat. Persantine also decreases the efficiency of anticholinesterases.

Other drugs may also interact with Persantine. So, it is necessary to inform your doctor about all the prescription/non prescription drugs that you are taking, before taking Persantine. You should also tell your doctor if you are taking any herbal medicine or vitamin and mineral supplements.

You should not start taking any new medicine, without consulting your doctor.

Persantine side effects

Side effects from Persantine include severe allergic reactions such as hives, breathing trouble, swelling of face, tongue, lips, or throat. Seek emergency medical help on appearance of such allergic symptoms. Also consult your doctor in case some other serious side-effects such as fast heartbeat, chest pain, swelling of throat and hepatitis occur.

Dizziness, headache, diarrhea, flushing, vomiting, stomach pain, fainting are some less serious side effects of Persantine. Alcohol, hot weather, fever or exercise may increase some of these side effects.