Evoxac (Cevimeline)

What is Evoxac?

Evoxac (cevimeline) is an oral drug which belongs to the class of drugs known as cholinergic agonists. It helps to increase the rate of saliva flow in the mouth.

What is Evoxac used for?

Evoxac is used in the treatment of dry mouth in patients with Sjögren’s Syndrome.

How does Evoxac work?

Evoxac is a cholinergic agonist and it binds to muscarinic receptors. Such agonists when used in adequate dosage increase secretion of the exocrine glands. This increases the amount of saliva in the mouth.

How to use Evoxac

Evoxac should be used in the manner prescribed by a doctor. The dosage depends on your medical condition and response to treatment.

Evoxac is usually taken orally thrice a day, with or without food.

The drug should be taken regularly, preferably at the same time every day, in order to get maximum benefit.

Signs of improvement in your conditions should start showing within 1-2 weeks of taking the drug. But it takes up to 6 weeks to get full benefit. 

Do not increase or stop your dose unless otherwise directed by your doctor. However, if your condition does not improve even after 6 weeks or becomes worse consult your doctor immediately.

Evoxac warnings and precautions

Evoxac is not administered to patients who are allergic to cevimeline.

Before taking the medication, inform your doctor about your medical conditions, especially if you are allergic to any other drug or if you have any of the following conditions: stomach problems (chronic heartburn, ulcer), certain eye conditions such as narrow-angle glaucoma, night blindness, acute iritis etc., heart diseases, breathing problems (asthma, bronchitis, chronic obstructive pulmonary disease), kidney or liver problems, depression, Alzheimer’s disease, psychoses, or gallbladder diseases. 

Evoxac increases sweating. So, you should take plenty of liquids to avoid dehydration.

The drug may also cause dizziness or night vision problems. You should avoid activities which require alertness or clear vision while taking the medication.

Evoxac may be harmful to a fetus. However it is not known whether it passes through breast milk. Therefore, pregnant and lactating women are advised to discuss the possible risks and benefits of taking the drug with their doctors.

What do I do if I have missed a Evoxac dose?

If you have missed an Evoxac dose, take it as soon as you remember. If, however, it is almost time for the next dose, the missed dose can be skipped. Do not take a double dose.

What do I do if I have taken a Evoxac overdose?

If you have taken an overdose of Evoxac, seek emergency medical attention.

Evoxac interactions

Some drugs which may interact with Evoxac are: antibiotics, antidepressants, medication for asthma, blood pressure or heart diseases and HIV/AIDS, cyclosporine, cimetidine, metronidazole, amiodarone etc.

Other drugs may also interact with Evoxac. Hence, it is necessary to inform your doctor about all the prescription/non prescription drugs/herbal medicines that you are taking, before taking the medication.

You should not start taking any new medicine, without consulting your doctor.

Evoxac side effects

Side effects from Evoxac include allergic reactions such as swelling of tongue, face, throat; hives, redness of skin etc. Seek emergency medical attention on appearance of such symptoms. Also, consult your doctor if you notice any of these serious side effects: eye pain, drainage, severe stomach pain, especially on the right side, extending up to right shoulder, fever, flu, chest pain, irregular heart rate, nausea, vomiting, jaundice, swelling of hands and feet, or shortness of breath.

Excessive sweating, drooling, salivating, nasal blockage or drainage, muscle pain, dry mouth, blurred vision, dry eyes, constipation, nausea, diarrhea, loss of appetite, vaginal itching or discharge are some less serious side effects of Evoxac.